ABSTRACT
Objectives: To create a dietary isoflavones scoring database for future use in cancer epidemiologic studies. To investigate the role of isoflavones in aetiology of prostate cancer
Materials and Methods: A population based case- control study was conducted on 525 cases and 843 controls. To create an isoflavones scoring database, a creditable phytoestrogens database, and data from publications were used to create a mathematical computerised calculation program. Then after obtaining isoflavone intake for each individual, an unconditional logistic regression with various models was carried out
Results: There are 131 food items in the Food Frequency Question [FFQ]. Isoflavones values have been assigned to 56 items out of 131. The results of the analysis to explore the role of isoflavones either as a continuous or quintile variable were not significant, not a single quintile of isoflavones showed any significant association with prostate cancer risk
Conclusion: The isoflavones scoring database has been created. The analysis of the young prostate cancer study dataset and the role of isoflavones in disease aetiology has not shown a statistically significant association